Coffee Consumption and Risk of Pancreatic Cancer: An Updated Meta-analysis of Cohort Studies
Keywords:
Coffee, Pancreatic cancer, Meta-analysisAbstract
Objective: To review the association between coffee consumption and risk of pancreatic cancer in a meta-analysis of cohort
studies and evaluate their dose–response relationship.Methods: We searched PubMed and EMBASE for cohort studies of coffee consumption and pancreatic cancer risk up to 5 January 2020. A fixed-effects model was used for pooling overall relative risk (RR) and corresponding 95% confidence interval (CI) for the highest versus lowest coffee consumption category, while the analysis was also stratified by sex, region and coffee type. Egger’s and Begg’s test was adopted to exam the publication bias. The dose-response analysis was performed as well. Results: A total of 21 high-quality studies from 18 publications were selected, including 2,859,065 participants and 11,023 pancreatic cancer cases. The pooled relative risk of 21 studies for highest versus lowest category of coffee consumption was 0.95 (95% CI 0.87-1.02, I2 = 43.4%, P for heterogeneity = 0.018). Subgroup analysis showed that coffee consumption was associated with a reduced pancreatic cancer risk in males (RR 0.72, 95%CI 0.53-0.91) but not in females (RR 0.89, 95% CI0.73-1.05). For dose-response analysis, the overall RR for increment of one cup/day of coffee consumption was 1.00 (95%CI, 0.99-1.02) of 15 studies, without statistically significant.Conclusions: This meta-analysis indicates non-significant association between coffee consumption and pancreatic cancer risk. No evidence of publication bias was found.
References
Liu, M., Ji, S., Xu, X., Yu, X. (2020) Advances in basic research, clinical diagnosis and treatment of pancreatic cancer in 2019. China Oncology, (01):1-10.
Siegel, RL. Miller, KD., Jemal, A. (2019) Cancer statistics, 2019. CA Cancer J Clin, 69(1): 7-34.
Feng, R,., Zong, YN., Cao, SM., Xu, RH. (2019) Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics? Cancer Commun (Lond), 39(1): 22.
Cornelis, MC. (2015) Toward systems epidemiology of coffee and health. Curr Opin Lipidol, 26(1): 20-29.
John Rozar Raj, B., Vishnu Priya, V., Gayathri, R. (2016) Relationship between coffee consumption and cancer- A review. Journal of pharmaceutical sciences and research, 8(6): 424-427.
Poole, R., Kennedy, OJ., Roderick, P., Fallowfield, JA., Hayes, PC., Parkes, J. (2017) Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes. BMJ, 359.
La Vecchia, C., Tavani, A. (2007) Coffee and cancer risk: an update. Eur J Cancer Prev, 16(5): 385-389.
Nie, K., Xing, Z., Huang, W., Wang, W., Liu, W. (2016) Coffee intake and risk of pancreatic cancer: an updated metaanalysis of prospective studies. Minerva Med, 107(4): 270-278.
Ran, HQ., Wang, JZ., Sun, CQ. (2016) Coffee Consumption and Pancreatic Cancer Risk: An Update Meta-analysis of Cohort Studies. Pak J Med Sci, 32(1): 253-259.
Yu, X., Bao, Z., Zou, J., Dong, J. (2011) Coffee consumption and risk of cancers: a meta-analysis of cohort studies. BMC Cancer, 11: 96.
Turati, F., Galeone, C., Edefonti, V., Ferraroni, M., Lagiou, P., La Vecchia, C., et al. (2012) A meta-analysis of coffee consumption and pancreatic cancer. Ann Oncol, 23(2): 311-318.
Li, TD., Yang, HW., Wang, P., Song, CH., Wang, KJ., Dai, LP., et al. (2019) Coffee consumption and risk of pancreatic cancer: a systematic review and dose-response metaanalysis. Int J Food Sci Nutr, 70(5): 519-529.
Zhou, CD., Kuan, AS., Reeves, GK., Green, J., Floud, S., Beral, V., et al. (2019) Coffee and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study. Int J Cancer, 145(6): 1484-1492.
Lukic, M., Nilsson, LM., Skeie, G., Lindahl, B., Braaten, T. (2018) Coffee consumption and risk of rare cancers in Scandinavian countries. Eur J Epidemiol, 33(3): 287-302.
Gapstur, SM., Anderson, RL., Campbell, PT., Jacobs, EJ., Hartman, TJ., Hildebrand, JS., et al. (2017) Associations of coffee drinking and cancer mortality in the cancer prevention study-II. Cancer Epidemiology Biomarkers and Prevention, 26(10): 1477-1486.
Greenland S, Longnecker MP. (1992) Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol, 135(11):1301–1309.
Guertin, KA., Freedman, ND., Loftfield, E., Stolzenberg- Solomon, RZ., Graubard, BI., Sinha, R. (2015) A prospective study of coffee intake and pancreatic cancer: Results from the NIH-AARP Diet and Health Study. Br J Cancer, 113(7): 1081-1085.
Bidel, S., Hu, G., Jousilahti, P., Pukkala, E., Hakulinen, T., Tuomilehto, J. (2013) Coffee consumption and risk of gastric and pancreatic cancer - A prospective cohort study. Int J Cancer, 132(7): 1651-1659.
Bhoo-Pathy, N., Uiterwaal, CSPM., Dik, VK., Jeurnink, SM., Bech, BH., Overvad, K., et al. (2013) Intake of coffee, decaffeinated coffee, or tea does not affect risk for pancreatic cancer: Results from the european prospective investigation into nutrition and cancer study. Clinical Gastroenterology and Hepatology, 11(11): 1486-1492.
Nilsson, LM., Johansson, I., Lenner, P., Lindahl, B., Van Guelpen, B. (2010) Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes Control, 21(10): 1533-1544.
Luo, J., Inoue, M., Iwasaki, M., Sasazuki, S., Otani, T., Ye, W., et al. (2007) Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study). Eur J Cancer Prev, 16(6): 542-548.
Khan, MM., Goto, R., Kobayashi, K., Suzumura, S., Nagata, Y., Sonoda, T.,et al. (2004) Dietary habits and cancer mortality among middle aged and older Japanese living in hokkaido, Japan by cancer site and sex. Asian Pac J Cancer Prev, 5(1): 58-65.
Stolzenberg-Solomon, RZ., Pietinen, P., Taylor, PR., Virtamo, J., Albanes, D. (2002) Prospective study of diet and pancreatic cancer in male smokers. Am J Epidemiol, 155(9): 783-792.
Lin, Y., Tamakoshi, A., Kawamura, T., Inaba, Y., Kikuchi, S., Motohashi, Y., et al. (2002) Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan collaborative cohort study for evaluation of cancer risk. Int J Cancer, 99(5): 742-746.
Isaksson, B., Jonsson, F., Pedersen, NL., Larsson, J., Feychtin, M., Permert, J. (2002) Lifestyle factors and pancreatic cancer risk: a cohort study from the Swedish Twin Registry. Int J Cancer, 98(3): 480-482.
Michaud, DS., Giovannucci, E., Willett, WC., Colditz , GA., Fuchs, CS. (2001) Coffee and alcohol consumption and the risk of pancreatic cancer in two prospective United States cohorts. Cancer Epidemiol Biomarkers Prev, 10(5): 429- 437.
Harnack, LJ., Anderson, KE., Zheng, W., Folsom, AR., Sellers, TA., Kushi, LH. (1997) Smoking, alcohol, coffee, and tea intake and incidence of cancer of the exocrine pancreas: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev, 6(12): 1081-1086.
Shibata, A., Mack, TM., Paganini-Hill, A., Ross, RK., Henderson, BE. (1994) A prospective study of pancreatic cancer in the elderly. Int J Cancer, 58(1): 46-49.
Zheng, W., McLaughlin, JK., Gridley, G., Bjelke, E., Schuman, LM., Silverman, DT., et al. (1993) A cohort study of smoking, alcohol consumption, and dietary factors for pancreatic cancer (United States). Cancer Causes Control, 4(5): 477-4782.
Mills, PK., Beeson, WL., Abbey, DE., Fraser, GE., Phillips, RL. (1988) Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer, 61(12): 2578-2585.
Hiatt, RA., Klatsky, AL., Armstrong, MA. (1988) Pancreatic cancer, blood glucose and beverage consumption. Int J Cancer, 41(6): 79.
Bøhn, SK., Blomhoff, R., Paur, I. (2014) Coffee and cancer risk, epidemiological evidence, and molecular mechanisms. Mol Nutr Food Res, 58(5): 915-930.
Alferink, LJM., Kiefte-de Jong, JC., Darwish Murad, S (2018) Potential Mechanisms Underlying the Role of Coffee in Liver Health. Semin Liver Dis, 38(3): 193-214.
Keijzers, GB., De Galan, BE., Tack, CJ., Smits, P. (2002) Caffeine can decrease insulin sensitivity in humans. Diabetes Care, 25(2): 364-369.
Dong, J., Zou, J., Yu, XF. (2011) Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies. World J Gastroenterol, 17(9): 1204-1210.
Platt, DE., Ghassibe-Sabbagh, M., Salameh, P., Salloum, AK., Haber, M., Mouzaya, F., et al. (2016) Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. Ann Nutr Metab, 68(1): 1-11.
Sartini, M., Bragazzi, NL., Spagnolo, AM., Schinca, E., Ottria, G., Dupont, C., et al. (2019) Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta- Analysis of Prospective Studies. Nutrients, 11(3): 694.
Cavin, C., Marin-Kuan, M., S. Langouët, C. Bezençon, G. Guignard, C. Verguet, D. Piguet, D. Holzhäuser, R. Cornaz and B. Schilter. (2008). Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver. Food Chem Toxicol, 46(4), 1239-1248.
Kalschne, DL., Biasuz, T., De Conti, AJ., Viegas, MC., Corso, MP., Benassi, MT. (2019) Sensory characterization and acceptance of coffee brews of C. arabica and C. canephora blended with steamed defective coffee. Food Res Int, 124: 234-238.
Rendón, MY., Dos Santos Scholz, MB., Bragagnolo, N. (2018) Physical characteristics of the paper filter and low cafestol content filter coffee brews. Food Res Int, 108: 280-285.
Rothwell, JA., Loftfield, E., Wedekind, R., Freedman, N., Kambanis, C., Scalbert, A., et al. (2019) A Metabolomic Study of the Variability of the Chemical Composition of Commonly Consumed Coffee Brews. Metabolites, 9(1): 7.
Zhou, Y., Tian, C., Jia, C. (2012) A dose-response metaanalysis of coffee consumption and bladder cancer. Prev Med, 55(1): 14-22.
Ferraroni, M., Tavani, A., Decarli, A., Franceschi, S., Parpinel, M., Negri, E., et al. (2004) Reproducibility and validity of coffee and tea consumption in Italy. Eur J Clin Nutr, 58(4): 674-680.
Bracken, MB., Triche, E., Grosso, L., Hellenbrand, K., Belanger, K., Leaderer, BP. (2002) Heterogeneity in assessing self-reports of caffeine exposure: implications for studies of health effects. Epidemiology, 13(2): 165- 171.
Wolpin, BM., Chan, AT., Hartge, P., Chanock, SJ., Kraft, P., Hunter, DJ., et al. (2009) ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst, 101(6): 424-431.
Wolpin, BM., Kraft, P., Gross, M., Helzlsouer, K., Buenode-Mesquita, HB., Steplowski, E., et al. (2010). Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res, 70(3): 1015-1023.
Bosetti, C., Lucenteforte, E., Silverman, DT., Petersen, G., Bracci, PM., Ji, BT., et al. (2012) Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4). Ann Oncol, 23(7): 1880-1888. Allen NE, Beral V, Casabonne D, et al. Moderate alcohol intake and cancer incidence in women (2009) J Natl Cancer Inst 101(5):296–305.
Allen NE, Beral V, Casabonne D, et al. (2009) Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst, 101(5):296–305.
Davoodi, SH., Malek-Shahabi, T., Malekshahi-Moghadam, A., Shahbazi R., Esmaeili, S. (2013) Obesity as an important risk factor for certain types of cancer. Iran J Cancer Prev, 6(4): 186-194.
Maisonneuve P., Lowenfels, AB. (2015) Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol, 44(1):186-198.
Midha, S., Chawla, S., Garg, PK. (2016) Modifiable and nonmodifiable risk factors for pancreatic cancer: A review. Cancer Lett, 381(1): 269-277. Stevens RJ, Roddam AW, Beral V. (2007) Pancreatic cancer in type 1 and youngonset diabetes: systematic review and meta-analysis. Br J Cancer, 96(3):507–509.
Stevens RJ, Roddam AW, Beral V. (2007) Pancreatic cancer in type 1 and young-onset diabetes: systematic review and meta-analysis. Br J Cancer, 96(3):507–509.
