Exposure to the Dietary Supplement N-Acetyl-LCysteine during Pregnancy Reduces Cyclophosphamide Teratogenesis in ICR Mice
Keywords:
n-acetyl-l-cysteine, Cyclophosphamide, Mice, Teratogenesis, ThiolAbstract
References
Dicke, J. (1989) Teratology: principles and practice. The Medical Clinics of North America, 73: 567-582.
Wells, P., McCallum, G., Chen, C., Henderson, JT., Lee, CJ., Perstin, J., et al. (2009) Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicological Sciences, 108(1): 4-18.
Atkuri, K., Mantovani, J., Herzenberg, L., Leonore H. (2007) N-Acetylcysteine – A safe antidote for cysteine/glutathione deficiency. Current Opinion in Pharmacology, 7(4): 355-359.
Ayash, L., Wright, J., Tetyakov, O., Gonin, R., Elias, A., Wheeler, C., et al. (1992) Cyclophosphamide pharmacokinetics: Correlation with cardiac toxicity and tumor response. Journal of Clinical Oncology, 10(6), 995-1000.
Moradi, M., Mojahedzadeh, M., Mandegari, A., Soltan-Sharifi, MS., Najafi, A., Khajavi, MR., et al. (2009). The role of glutathione-S- transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine. Respir Med, 103(3): 434-441.
Hales, BF. (1982) Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolies, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein. Cancer Res, 42(8): 3016-3021.
Hales, B., Jain, R. (1980) Characteristics of the activation of cyclophosphamide to a mutagen rat liver. Biochemical Pharmacology, 29(2): 256-259.
Latorre, A., Hueza, I., Gorniak, S. (2007) Association of Ipomoea carnea and BCG reduces birth defects caused by cyclophosphamide in rats. Life Sci, 80(5): 430-435.
Mirkes, P. (1985) Cyclophosphamide teratogenesis: a review. Teratog Carcinog Mutagen, 5(2): 75-88.
Slott, V., Hales, F. (1988) Role of the 40hydroxy intermediate in the in vitro embryotoxicigy of cyclophosphamide and dechlorocyclophosphamide. Tox and App Pharm, 92: 170-178.
Little, A., Mirkes, E. (1987) DNA cross-linking and singlestrand breaks induced by teratogenic concentrations of 4-hydroperoxycyclophosphamide and phosphoramide mustard in postimplantation rat embryos. Cancer Res, 47(20): 5421-5426.
Wells, PG, Winn, LM. (1996) Biochemical toxicology of chemical teratogenesis. Crit Rev Biochem Mol Biol, 31(1): 1-40.
Tsai-Turton, M., Luong, B., Tan, Y., Luderer, U. (2007). Cyclophosphosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion. Toxicol Sci, 98(1): 216-230.
Hansen, J. (2006) Oxidative stress as a mechanism of teratogenesis. Birth Defects Res C Embryo Today, 78(4): 293-307.
Frei, B., Higdon, J. (2003). Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J Nutr, 133(10): 3275-3284.
Halliwell, B. (1996) Antioxidants in human health and disease. Annu Rev Nutr, 16: 33-50.
Fliege, R., Metzler, M. (2000) Electrophilic properties of patulin, N-acetylcysteine and glutathione adducts. Chem Res Toxicol, 13(5): 373-381.
Chu, KO., Wang, CC., Chu, CY., Choy, KW., Pang, CP., Rogers, MS. (2007) Uptake and distribution of catechins in fetal organs following in utero exposure in rats. Human Reprod, 22(1): 280-287.
Logsdon, AL., Herring, BJ., Lockard, JE., Miller, BM., Kim, H., Hood, RD., et al. (2012). Exposure to green tea extract alters the incidence of specific cyclophosphamide-induced malformations. Birth Defects Res B Dev Reprod Toxicol, 95(3): 231-237.
De Flora, S., Izzotti, A., D’Agostini, F., Balansky, RM. (2001) Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis, 22(7): 999-1013.
Wolf, SJ., Heard, K., Sloan, EP., Jagoda, AS. (2007) Clinical policy: critical issues in the management of patients presenting to the emergency department with acetaminophen overdose. Ann Emerg Med, 50(3): 292-313.
Whyte, I., Francis, B., Dawson, A. (2007) Safety and efficacy of intravenous N-acetylcysteine for acetaminophen overdose: analysis of the Hunter Area Toxicology Service (HATS) database. Curr Med Res Opin, 23(10): 2359-2368.
Erkkila, K., Hirvonen, V., Wuokko, E., Parvinen, M., Dunkel, l. (1998) N-acetyl-L-cysteine inhibits apoptosis in human male germ cells in vitro. Journal of Clinical Endocrinology and Metabolism, 83(7): 2523- 2531.
Meyer, A., Buhl, R., Magnussen, H. (1994) The effect of oral N-acetylcysteine on lunch glutathione levels in idiopathic pulmonary fibrosis. Eur Respir J, 7(3): 431-436.
Dekhuijzen, PN. (2004) Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J, 23(4): 629-636.
Ornaghi, F., Ferrini, S., Prati, M., Giavini, E. (1992) The protective effects of N-acteyl-L-cysteine against methyl mercury embryotoxicity in mice. Fundamental and Applied Toxicology, 20(4): 437-445.
Hales, B. (1981) Modification of the teratogenicity and mutagenicity of cyclophosphamide with thiol compounds. Teratology, 23(3): 373-381.
Lahdetie, J., Raty, R., Sorsa, M. (1990) Interaction of Mesna (2-mercaptoethane sulfonate) with the mutagenicity of cyclophosphamide in vitro and in vivo. Mutat Res, 245(1): 27-32.
Varzi, H., Mahabadi, M. (2009) A comparison study of the effects of Echinacea purpureaethanolic extract and mesna on cyclophosphamide-induced macroscopic fetal defects in rats. Iranian Journal of Basic Medical Sciences, 12(1): 61-66.
Slott, V., Hales, B. (1986) Sodium 2-mercaptoenthane sulfonate protection against cyclophosphamide-induced teratogenicity in rats. Toxicology and Applied Pharmacology, 82(1): 80-86.
Webb, G., Byrd, R. (1994) Simultaneous differential staining of cartilage and bone in rodent fetuses: anAlcian blue and alizarin red S procedure without glacial acetic acid. Biotech Histochem, 69(4): 181- 185.
De Vries, N., De Flora, S. (1993) N-Acetyl-l-Cysteine. Journal of Cellular Biochemistry, 53(17): 270-277.
Van Schooten, FJ., Besaratinia, A., De Flora, S., D’Agostini, F., Izzotti, A., Camoirano, A., et al. (2005) Effects of oral administration of N-acetyl- L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol, Biomarkers Prev, 11(2): 167-175.
Klaassen, C. (2013) Cassarett & Doull’s toxicology. (8thedn), New York: McGraw-Hill, USA.
Botta, JA., Nelson, LW., Wieker, JH. (1973) Acetylcysteine in the prevention of cyclophosphamide-induced cystitis in rats. Journal of the National Cancer Institute, 51(3): 1051-1058.
Doroshow, J., Locker, G., Ifrim, I., Myers, CE. (1981) Prevention of doxorubicin cardiac toxicity in the mouse by N-Acetylcysteine. J Clin Invest, 68(4): 1053-1064.
