Phosphatidylserine: A Well-Studied Cognitive Solution for Supplements and Functional Foods
Abstract
References
Yeung, T., Gilbert, GE., Shi, J., Silvius, J., Kapus, A., Grinstein S. (2008) Membrane phosphatidylserine regulates surface charge and protein localization. Science, 319(5860): 210-213.
Svennerholm, L. (1968) Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res, 9(5): 570-579.
Folch, J. (1948) The chemical structure of phospatidyl serine. J Biol Chem, 174(2): 439-450.
Folch, J. (1949) Complete fractionation of brain cephalin; isolation from it of phosphatidyl serine, phosphatidyl ethanolamine, and diphosphoinositide. J Biol Chem, 177(2): 497-504.
Newton, AC. (1995) Protein kinase C: structure, function, and regulation. J Biol Chem, 270(48): p. 28495-28498.
Akbar, M., Calderon, F., Wen, Z., Kim, HY (2005) Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. Proc Natl Acad Sci U S A, 102(31): 10858-10863.
Sun, MK., Alkon, DL. (2010) Pharmacology of protein kinase C activators: cognition-enhancing and antidementic therapeutics. Pharmacol Ther, 127(1): 66-77.
Gianotti, C., Porta, A., De Graan, PN., Oestreicher, AB., Nunzi, MG. (1993) B-50/GAP-43 phosphorylation in hippocampal slices from aged rats: effects of phosphatidylserine administration. Neurobiol Aging, 14(5): 401-416.
Borghese, CM., Gomez, RA., Ramirez, OA. (1993) Phosphatidylserine increases hippocampal synaptic efficacy. Brain Res Bull, 31(6): 697- 700.
Sharma, D., Sethi, P., Hussain, E., Singh, R. (2009) Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions. Biogerontology, 10(4): 489-502.
Lee, MH., Bell, RM. (1992) Supplementation of the phosphatidyl- L-serine requirement of protein kinase C with nonactivating phospholipids. Biochemistry, 31(22): 5176-5182.
Bell, RM., Burns, DJ. (1991) Lipid activation of protein kinase C. J Biol Chem, 266(8): 4661-4664.
Bitman, J., Wood, DL., Mehta, NR., Hamosh, P., Hamosh, M. (1984) Comparison of the phospholipid composition of breast milk from mothers of term and preterm infants during lactation. Am J Clin Nutr, 40(5): 1103-1119.
Ammassari-Teule, M., Fagioli, S., Maritati, M., Populin, R., Pavone, F. (1990) Chronic administration of phosphatidylserine during ontogeny enhances subject-environment interactions and radial maze performance in C57BL/6 mice. Physiol Behav, 47(4): 755-760.
Fagioli, S., Castellano, C., Oliverio, A., Pavone, F., Populin, R., Toffano, G. (1989) Phosphatidylserine administration during postnatal development improves memory in adult mice. Neurosci Lett, 101(2): 229-233.
Hamm, M. (2002) Nutritional-scientific statement on the change of nutritive provision with phosphatidylserine.
McDaniel, MA., Maier SF., Einstein, GO. (2003) “Brain-specific” nutrients: a memory cure? Nutrition, 19(11-12): 957-975.
Palmieri, G. (1987) Double blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clinical Trials Journal, 24(1): 73-83.
Villardita, C. (1987) Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clinical Trials Journal, 24(1): 84-93.
Cenacchi, T., Baggio, C., Palin, E. (1987) Human tolerability of oral phosphatidylserine assessed through laboratory examinations. Clin trials J, 24: 125-130.
Crook, TH., Feher, EP., Larrabee, GJ. (1992) Assessment of memory complaint in age-associated memory impairment: the MAC-Q. Int Psychogeriatr, 4(2): 165-176.
Crook, TH., Tinklenberg, J., Yesavage, J., Petrie, W., Nunzi, MG., Massari, DC. (1991) Effects of phosphatidylserine in age-associated memory impairment. Neurology, 41(5): 644-649.
Cenacchi, T., Bertoldin, T., Farina, C., Fiori, MG., Crepaldi, G. (1993) Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano), 5(2): 123-133.
Crook, T., Petrie, W., Wells, C., Massari, DC. (1992) Effects of phosphatidylserine in Alzheimer’s disease. Psychopharmacol Bull, 28(1): 61-66.
Crook, T. (1998) Treatment of age-related decline in cognitive capacities: The effects of phosphatidylserine, in Anti-Aging Medical Therapeutics,, Katz, RM, and Goldman, Editors. 20-28.
Gindin, J. (1995) Effect of soy lecithin phosphatidylserine (ps) complex on memory impairment and mood in the functioning elderly Unpublished Report. Lipogen, Ltd.; Israel.
Manor, I., Magen, A., Keidar, D., Rosen, S., Tasker, H., Cohen, T., et al. (2013) Safety of phosphatidylserine containing omega3 fatty acids in ADHD children: a double-blind placebo-controlled trial followed by an open-label extension. Eur Psychiatry, 28(6): 386-391.
Manor, I., Magen, A., Keidar, D., Rosen, S., Tasker, H., Cohen, T., et al. (2012) The effect of phosphatidylserine containing Omega3 fatty-acids on attention-deficit hyperactivity disorder symptoms in children: A double-blind placebo-controlled trial, followed by an open-label extension. Eur Psychiatry, 27(5): 335-342.
Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., Kam, Y., Korczyn, AD. (2014) Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geriatr Cogn Disord, 38(1-2): 39-45.
Vakhapova, V., Richter, Y., Cohen, T., Herzog, Y., Korczyn, AD. (2011) Safety of phosphatidylserine containing omega-3 fatty acids in nondemented elderly: a double-blind placebo-controlled trial followed by an open-label extension. BMC Neurol, 11: 79.
Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y., Korczyn, AD. (2010) Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial. Dement Geriatr Cogn Disord, 29(5): 467-474.
Kato-Kataoka, A., Sakai, M., Ebina, R., Nonaka, C., Asano, T., Miyamori, T. (2010) Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints. J Clin Biochem Nutr, 47(3): 246-255.
Yong, T., Qianyong, Z., Mantian, M., Gang, H., Jing, W. (2011) Research on human memory enhancement by phosphatidylserine fortified milk. Chongqing Medicine, 40(30): 3022-3023.
APA. Impact of Stress. 2012; Available from: http://www.apa.org/ news/press/releases/stress/2012/impact.aspx.
Lovallo, WR., Pincomb, GA., Edward,s GL., Brackett, DJ., Wilson, MF. (1986) Work pressure and the type A behavior pattern exam stress in male medical students. Psychosom Med, 48(1-2): 125-133.
Savendahl, L. (2012) The effect of acute and chronic stress on growth. Sci Signal, 5(247): pt9.
Miller, GE., Chen, E., Zhou, ES. (2007) If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull, 133(1): 25-45.
Heshmati, HM., Riggs, BL., Burritt, MF., McAlister, CA., Wollan, PC., Khosla, S. (1998) Effects of the circadian variation in serum cortisol on markers of bone turnover and calcium homeostasis in normal postmenopausal women. J Clin Endocrinol Metab, 83(3): 751-756.
Simmons, PS., Miles, JM., Gerich, JE., Haymond, MW. (1984) Increased proteolysis. An effect of increases in plasma cortisol within the physiologic range. J Clin Invest, 73(2): 412-420.
Monteleone, P., Beinat, L., Tanzillo, C., Maj, M., Kemali, D. (1990) Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinology, 52(3): 243-248.
Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. (1992) Blunting by chronic phosphatidylserine administration of the stressinduced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol, 41(4): 385-388.
Hellhammer, J., Fries, E., Buss, C., Engert, V., Tuch, A., Rutenberg, D., et al. (2004) Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress, 7(2): 119-126.
Benton, D., Donohoe, RT., Sillance, B., Nabb, S. (2001) The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutr Neurosci, 4(3): 169-178.
Starks, MA., Starks, SL., Michael K., Martin, P., Ralf, J. (2008) The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr, 5: 11.
Ralf, J., Martin, P., Kurt-Reiner, G., Michael, W., Jochen, B., Francesco, A., et al. (2007) The effect of phosphatidylserine on golf performance. J Int Soc Sports Nutr, 4: 23.
Mooradian, A.D., Morley, JE., Korenman, SG. (1987) Biological Actions of Androgens. Endocrine Reviews, 8(1): 1-28.
Hochreiter-Hufford, AE., Lee, CS., Kinchen, JM., Sokolowski, JD., Arandjelovic, S., Call, JA., et al. (2013) Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature, 497(7448): 263-267.
Kingsley, MI., Wadsworth, D., Kilduff, LP., McEneny, J., Benton, D. (2005) Effects of phosphatidylserine on oxidative stress following intermittent running. Med Sci Sports Exerc, 37(8): 1300-1306.
Fernholz, KM., (1997) The Effects Of Phosphatldylserine On Markers Of Muscular Stress In Endurance Runners. St. Cloud State University.
Kingsley, MI., Miller, M., Kilduff, LP., McEneny, J., Benton, D., (2006) Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc, 38(1): 64-71.
Cho, S., Kim, HH., Lee, MJ., Lee, S., Park, CS., Nam, SJ., et al. (2008) Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo. J Lipid Res, 49(6): 1235-1245.
Choi, H.D., Jeong, JH., JI-Hee, Y., Sang-Hong, L., Yun-Suk, K., Guk-Hoon, C., et al. (2013) Effect of Soy Phosphatidylserine Supplemented Diet on Skin Wrinkle and Moisture in Vivo and Clinical Trial. J Korean Soc Appl Biol Chem, 56: 227-235.
Sang Hoon, L., Ji-Hee, Y., Yong-Kon, P., Jeong-Jun, H., Guk-Hoon, C., Dae-hyun, H., et al. (2013) Protective effect and mechanism of phosphatidylserine in UVB-induced human dermal fibroblasts. European Journal of Lipid Science and Technology, 115(7): 783-790.
Baumeister, J., Barthel, T., Geiss, KR., Weiss, M. (2008) Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress. Nutr Neurosci, 11(3): 103-110.
Hirayama, S., Terasawa, K., Rabeler R., Hirayama, T., Inoue, T., Tatsumi, Y., et al. (2013) The effect of phosphatidylserine administration on memory and symptoms of attention-deficit hyperactivity disorder: a randomised, double-blind, placebo-controlled clinical trial. J Hum Nutr Diet, 2: 284-291.
Simopoulos, AP. (2002) The importance of the ratio of omega-6/ omega-3 essential fatty acids. Biomed Pharmacother, 56(8): 365-379.
Komori, T. (2015) The Effects of Phosphatidylserine and Omega-3 Fatty Acid-Containing Supplement on Late Life Depression. Ment Illn, 7(1): 5647.
Wells, AJ., Hoffman, JR., Gonzalez, AM., Stout, JR., Fragala, MS., Mangine, GT., et al. (2013) Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans. Nutr Res, 33(6): 464-472.
Fahey, TD., Pearl, MS. (1998) The Hormonal and Perceptive effects of phosphatidylserine administrtion during tow weeks of resistive exercise induced overtraining. Biology of sport, 15(3): 136-144.
Kris-Etherton, PM., Harris, WS., Appel, LJ. (2002) American Heart Association. Nutrition Committee. et al., Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation, 106(21): 2747-2757.
