Relapses in MS Patients Treated with DMF with no Variation in Lymphocyte Counts

Authors

  • C. Fjeldstad-Pardo Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK, USA Author
  • T. Reyna Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK, USA Author
  • J. Smith Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK, USA Author
  • T. Sharp Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK, USA Author
  • G. Pardo Oklahoma Medical Research Foundation, Multiple Sclerosis Center of Excellence, Oklahoma City, OK, USA Author

Abstract

Graphical abstract

Relapses in MS Patients Treated with DMF with no Variation in Lymphocyte Counts

References

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Scannevin, RH., Chollate, S., Jung, MY., Shackett, M., Patel, H., Bista, P., et al. (2012) Fumarates promote cytoprotection of central nervous system cells against oxidative stress via the nuclear factor (erythroidderived 2)-like 2 pathway. J Pharmacol Exp Ther, 341(1): 274-284.

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Chaves, C., Ganguly, R., Ceresia, C., Camac, A. (2017) Lymphocyte subtypes in relapsing-remitting multiple sclerosis patients treated with dimethyl fumarate. Mult Scler J Exp Transl Clin, 3(2): 2055217317702933.

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Fox, RJ., Miller, DH., Phillips, JT., Hutchinson, M., Havrdova, E., Kita, M., et al. (2012) Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med, 367(12): 1087-1097.

Gold, R., Kappos, L., Arnold, DL., Bar-Or, A., Giovannoni, G., Selmaj, K., et al. (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med, 367(12): 1098-1107.

Fox, RJ., Chan, A., Gold, R., Phillips, JT., Selmaj, K., Chang, I., et al. (2016) Characterizing absolute lymphocyte count profiles in dimethyl fumarate-treated patients with MS: Patient management considerations. Neurol Clin Pract, 6(3): 220-229.

Longbrake, EE., Naismith, RT., Parks, BJ., Wu, GF., Cross, AH. (2015) Dimethyl fumarate-associated lymphopenia: Risk factors and clinical significance. Mult Scler J Exp Transl Clin, 1.

Graphical abstract

Published

2019-07-18

Issue

Section

Articles

How to Cite

Relapses in MS Patients Treated with DMF with no Variation in Lymphocyte Counts. (2019). Current Research in Neurology and Neurosurgery, 2(1). https://somatopub.com/index.php/CRNN/article/view/234