Benign Hybrid Schwannoma-Perineurioma of the Gastric Wall: A Report of Three Cases
Keywords:
Hybrid peripheral nerve sheath tumors, Schwannoma, PerineuriomaAbstract
We present three cases of benign hybrid peripheral nerve sheath tumors of the stomach. Endoscopy revealed a gastric mass in all cases; thus, a partial gastrectomy was performed. Gross examination revealed gastric masses extending through the wall. Histologically, the tumor cells were bland, spindled, with tapered and often wavy nuclei in a loose fibromyxoid stroma formation. On the basis of hematoxylin-eosin (H&E) stain analysis, the differential diagnosis included schwannomas, perineuriomas, leiomyomas, and gastrointestinal stromal tumors. Immunohistochemistry revealed diffuse immunostaining for S-100 protein and multifocal positivity for epithelial membrane antigen, Glut-1, and Claudin-1 in all three cases. CD117, DOG1, actin and neurofilament protein were uniformly negative. Based on the histopathology and immunophenotype, these tumors are classified as benign hybrid schwannoma-perineuriomas. They cases presented
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