Impact of noninvasive ventilation on Quality of Life in Patients with persistent asthma

Priya Kapoor; V. Chatterjee; V. Sharma

doi:10.5281/zenodo.22815243

Authors

Priya Kapoor Department of Pulmonary Medicine, Zambezi Center for Pulmonary Medicine Author https://orcid.org/7170-1373-7142-6448
V. Chatterjee Department of Clinical Respiratory Care, Tigris Research Center for Pulmonary Medicine Author https://orcid.org/2578-4127-7372-778X
V. Sharma Department of Respiratory Care, Amazon Center for Pulmonary Medicine Author https://orcid.org/7006-6503-4471-922X

DOI:

https://doi.org/10.5281/zenodo.22815243

Keywords:

noninvasive ventilation, persistent asthma, status asthmaticus, quality of life, respiratory failure

Abstract

Graphical abstract

Background: Severe exacerbations of persistent asthma can progress rapidly to ventilatory failure, and invasive mechanical ventilation of a bronchospastic airway carries substantial morbidity, prompting growing use of noninvasive ventilation (NIV) as a bridge that unloads the respiratory muscles while pharmacotherapy takes effect.

Objective: This review synthesizes the evidence on NIV use in severe and persistent asthma and evaluates its documented and inferred impact on asthma-specific health-related quality of life, using validated instruments as the organizing framework.

Methods: We synthesized randomized controlled trials, a Cochrane systematic review, multicenter observational cohorts, pediatric status asthmaticus studies, and the parallel literature relating asthma control and psychological burden to standardized quality-of-life questionnaires.

Findings: Trial and cohort data show that early, well-tolerated NIV reduces intubation rates and shortens length of stay in adults and children with severe asthma exacerbations without added harm, while a distinct body of evidence links uncontrolled asthma severity and psychological distress to markedly lower Asthma Quality of Life Questionnaire scores, together suggesting that avoiding intubation through successful NIV plausibly protects quality of life beyond the immediate exacerbation.

Conclusions: NIV is a physiologically rational and increasingly evidence-supported bridge therapy in appropriately selected patients with severe persistent asthma; direct measurement of asthma-specific quality of life as an outcome of ventilatory strategy remains an important gap for future prospective study.

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