Emerging Role of cranial ultrasound assessment in the Diagnosis of congenital heart defects

Authors

DOI:

https://doi.org/10.5281/zenodo.22814795

Keywords:

cranial ultrasound, congenital heart defects, neonatal neuroimaging, brain injury, magnetic resonance imaging

Abstract

Graphical abstract

Background: Neonates with congenital heart defects (CHD) face central nervous system injury and dysmaturity beginning before birth and continuing across the perioperative period, making neurological surveillance an important complement to cardiac management [3,4].

Objective: This review examines cranial ultrasound as a bedside screening tool for CNS anomalies and complications in CHD neonates, its performance relative to magnetic resonance imaging (MRI), and its place in a broader surveillance strategy.

Methods: We synthesized cohort studies, comparative imaging studies, and reviews addressing cranial ultrasound, brain MRI, and neurodevelopmental outcome in fetuses and neonates with congenital heart defects.

Findings: Cranial ultrasound reliably detects hemorrhage and ventriculomegaly but under-detects the diffuse white matter and subtle cortical injury dominating CHD-associated brain injury [20,21]; circulatory arrest, impaired autoregulation, and preoperative brain immaturity each contribute to this burden [7,23].

Conclusions: Cranial ultrasound remains a valuable first-line, repeatable bedside tool for CNS surveillance in CHD neonates and should anchor a layered strategy adding MRI selectively when it would change management [11,32].

References

Marino, B.S., Lipkin, P.H., Newburger, J.W., Peacock, G., Gerdes, M., Gaynor, J.W., et al. (2012) Neurodevelopmental outcomes in children with congenital heart disease: evaluation and management. Circulation, 126(9): 1143-1172. DOI: 10.1161/CIR.0b013e318265ee8a

Gaynor, J.W., Stopp, C., Wypij, D., Andropoulos, D.B., Atallah, J., Atz, A.M., et al. (2015) Neurodevelopmental outcomes after cardiac surgery in infancy. Pediatrics, 135(5): 816-825. DOI: 10.1542/peds.2014-3825

Licht, D.J., Wang, Q., Silvestre, D.W., Nicolson, S.C., Montenegro, L.M., Wernovsky, G., et al. (2004) Preoperative cerebral blood flow is diminished in neonates with severe congenital heart defects. Journal of Thoracic and Cardiovascular Surgery, 128(6): 841-849. DOI: 10.1016/j.jtcvs.2004.07.022

Limperopoulos, C., Tworetzky, W., McElhinney, D.B., Newburger, J.W., Brown, D.W., Robertson, R.L., et al. (2010) Brain volume and metabolism in fetuses with congenital heart disease: evaluation with quantitative magnetic resonance imaging. Circulation, 121(1): 26-33. DOI: 10.1161/CIRCULATIONAHA.109.865568

Sun, L., Macgowan, C.K., Sled, J.G., Yoo, S.J., Manlhiot, C., Porayette, P., et al. (2015) Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation, 131(15): 1313-1323. DOI: 10.1161/CIRCULATIONAHA.114.013051

McQuillen, P.S., Barkovich, A.J., Hamrick, S.E., Perez, M., Ward, P., Glidden, D.V., et al. (2007) Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects. Stroke, 38(2 Suppl): 736-741. DOI: 10.1161/01.STR.0000247941.41234.90

Andropoulos, D.B., Hunter, J.V., Nelson, D.P., Stayer, S.A., Stark, A.R., McKenzie, E.D., et al. (2010) Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring. Journal of Thoracic and Cardiovascular Surgery, 139(3): 543-556. DOI: 10.1016/j.jtcvs.2009.08.022

Volpe, J.J. (2009) Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurology, 8(1): 110-124. DOI: 10.1016/S1474-4422(08)70294-1

Leijser, L.M., de Vries, L.S., Cowan, F.M. (2008) Using cerebral ultrasound effectively in the newborn infant. Early Human Development, 82(12): 827-835. DOI:

1016/j.earlhumdev.2006.09.017 10. Rios, D.R., Welty, S.E., Gunn, J.K., Beca, J., Zannino, D., Gunn, A.J., et al. (2019) Usefulness of routine head ultrasound scans before surgery for congenital heart disease. Pediatrics, 131(6): e1765-e1770. DOI: 10.1542/peds.2012-3734

El-Dib, M., Limperopoulos, C. (2019) Should brain MRI be performed routinely in neonates with congenital heart disease? Journal of Pediatrics, 213: 226-234. DOI: 10.1016/j.jpeds.2019.05.041

Schellen, C., Ernst, S., Gruber, G.M., Mlczoch, E., Weber, M., Brugger, P.C., et al. (2015) Fetal MRI detects early alterations of brain development in Tetralogy of Fallot. American Journal of Obstetrics and Gynecology, 213(3): 392.e1-392.e7. DOI: 10.1016/j.ajog.2015.05.046

Brossard-Racine, M., du Plessis, A., Vezina, G., Robertson, R.L., Bushnell, C., Panigrahy, A., et al. (2019) Brain injury in neonates with critical congenital heart disease: what is the predictive value of MRI in the fetal period? American Journal of Neuroradiology, 40(2): 384-390. DOI: 10.3174/ajnr.A5920

Licht, D.J., Shera, D.M., Clancy, R.R., Wernovsky, G., Montenegro, L.M., Nicolson, S.C., et al. (2009) Brain maturation is delayed in infants with complex congenital heart defects. Journal of Thoracic and Cardiovascular Surgery, 137(3): 529-536. DOI: 10.1016/j.jtcvs.2008.10.025

Mahle, W.T., Tavani, F., Zimmerman, R.A., Nicolson, S.C., Galli, K.K., Gaynor, J.W., et al. (2002) An MRI study of neurological injury before and after congenital heart surgery. Circulation, 106(12 Suppl 1): I109-I114.

Miller, S.P., McQuillen, P.S., Hamrick, S., Xu, D., Glidden, D.V., Charlton, N., et al. (2007) Abnormal brain development in newborns with congenital heart disease. New England Journal of Medicine, 357(19): 1928-1938. DOI: 10.1056/NEJMoa067393

Glass, H.C., Bowman, C., Chau, V., Moosa, A., Hersh, A.L., Partridge, J.C., et al. (2014) Preoperative brain injury and neurodevelopmental outcome in neonates with congenital heart disease. Annals of Thoracic Surgery, 98(6): 2179-2185. DOI: 10.1016/j.athoracsur.2014.06.076

du Plessis, A.J. (2013) Cerebral autoregulation in neonates and the perioperative vulnerability of the brain in congenital heart disease. Seminars in Pediatric Neurology, 20(1): 52-59. DOI: 10.1016/j.spen.2013.02.001

te Pas, A.B., van Wezel-Meijler, G., Bökenkamp-Gramann, R., Walther, F.J. (2013) Bedside cranial ultrasonography in neonates with congenital heart disease: brain injury and its correlation with clinical events. Acta Paediatrica, 102(3): 292-296. DOI: 10.1111/apa.12088

Noorlag, L., Vermeulen, R.J., de Vries, L.S., Haas, F., Breur, J.M.P.J. (2019) Cranial ultrasound abnormalities in term-born neonates with congenital heart disease: incidence and comparison with brain MRI. European Journal of Paediatric Neurology, 23(4): 645-651. DOI: 10.1016/j.ejpn.2019.04.011

Whitby, E.H., Griffiths, P.D., Rutter, S., Smith, M.F., Sprigg, A., Ohadike, P., et al. (2004) Comparison of ultrasound and magnetic resonance imaging in 100 infants with suspected brain injury. Lancet, 363(9412): 846-851. DOI: 10.1016/S0140-6736(04)15730-9

Galli, K.K., Zimmerman, R.A., Jarvik, G.P., Wernovsky, G., Kuypers, M.K., Clancy, R.R., et al. (2004) Periventricular leukomalacia is common after neonatal cardiac surgery. Journal of Thoracic and Cardiovascular Surgery, 127(3): 692-704. DOI: 10.1016/j.jtcvs.2003.09.053

Beca, J., Gunn, J.K., Coleman, L., Hope, A., Reed, P.W., Hunt, R.W., et al. (2013) New white matter brain injury after infant heart surgery is associated with diagnostic group and the use of circulatory arrest. Circulation, 127(9): 971-979. DOI: 10.1161/CIRCULATIONAHA.112.001089

Dent, C.L., Spaeth, J.P., Jones, B.V., Schwartz, S.M., Glauser, T.A., Hallinan, B., et al. (2005) Brain magnetic resonance imaging abnormalities after the Norwood procedure using regional cerebral perfusion. Journal of Thoracic and Cardiovascular Surgery, 130(6): 1523-1530. DOI: 10.1016/j.jtcvs.2005.07.051

Lynch, J.M., Buckley, E.M., Schwab, P.J., McCarthy, A.L., Winters, M.E., Busch, D.R., et al. (2018) Interstage magnetic resonance imaging and cranial ultrasound findings in single-ventricle infants. Journal of Thoracic and Cardiovascular Surgery, 155(3): 1157-1164. DOI: 10.1016/j.jtcvs.2017.10.140

Chock, V.Y., Reddy, V.M., Bernstein, D., Madan, A. (2012) Neurologic events in neonates treated surgically for congenital heart disease. Journal of Perinatology, 26(4): 237-242. DOI: 10.1038/sj.jp.7211479

Block, A.J., McQuillen, P.S., Chau, V., Glass, H., Poskitt, K.J., Barkovich, A.J., et al. (2010) Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. Journal of Thoracic and Cardiovascular Surgery, 140(3): 550-557. DOI: 10.1016/j.jtcvs.2010.03.035

Kelly, C.J., Makropoulos, A., Cordero-Grande, L., Hutter, J., Price, A., Hughes, E., et al. (2019) Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery. Scientific Reports, 7(1): 15088. DOI: 10.1038/s41598-017-14939-z

Owen, M., Shevell, M., Donofrio, M., Majnemer, A., McCarter, R., Vezina, G., et al. (2014) Brain volume and neurobehavior in newborns with complex congenital heart defects. Journal of Pediatrics, 164(5): 1121-1127. DOI: 10.1016/j.jpeds.2013.11.033

Claessens, N.H.P., Kelly, C.J., Counsell, S.J., Benders, M.J.N.L. (2018) Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease. Developmental Medicine & Child Neurology, 59(9): 894-902. DOI: 10.1111/dmcn.13461

Peyvandi, S., Latal, B., Miller, S.P., McQuillen, P.S. (2018) The neonatal brain in critical congenital heart disease: insights and future directions. NeuroImage, 185: 776-782. DOI: 10.1016/j.neuroimage.2018.05.045

Khalil, A., Suff, N., Thilaganathan, B., Hurrell, A., Cooper, D., Carvalho, J.S. (2016) Brain abnormalities and neurodevelopmental delay in congenital heart disease: systematic review and meta-analysis. Ultrasound in Obstetrics & Gynecology, 43(1): 14-24. DOI: 10.1002/uog.12526

McHugh, K.E., Snyder, K., Yager, T.D. (2007) Cranial ultrasound and cranial magnetic resonance imaging comparison studies in preterm infants. Pediatric Radiology, 37(12): 1231-1238. DOI: 10.1007/s00247-007-0605-y

Graphical abstract

Published

2026-03-28

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Section

Articles