A Retrospective Cohort Study of robotic-assisted surgery in elderly surgical patients with cholelithiasis
DOI:
https://doi.org/10.5281/zenodo.22813457Keywords:
Robotic-assisted surgery, Laparoscopic cholecystectomy, Cholelithiasis, Elderly, Retrospective cohort studyAbstract

Background: Robotic-assisted cholecystectomy has expanded rapidly, but comparative outcome data specific to elderly patients with cholelithiasis remain limited. This study compares robotic-assisted cholecystectomy (RAC) with conventional laparoscopic cholecystectomy (LC) in patients aged 65 years and older.
Methods: We conducted a retrospective cohort study of patients aged 65 years or older undergoing RAC or LC for cholelithiasis between January 2016 and December 2023. Propensity score matching (1:1) on age, sex, body mass index, ASA class, Charlson Comorbidity Index, and indication yielded 148 matched pairs. Perioperative outcomes, 30-day Clavien-Dindo complications, readmission, and mortality were compared.
Results: Operative time was longer with RAC (94.6 vs 68.2 minutes, p<0.001), while conversion to open surgery was lower (3.7% vs 9.5%, p=0.038), length of stay was shorter (median 1 vs 2 days, p=0.006), and 30-day complications were fewer (12.8% vs 21.6%, p=0.041). Bile duct injury, readmission, and mortality were low and did not differ significantly between groups.
Conclusion: In elderly patients with cholelithiasis, robotic-assisted cholecystectomy was associated with a lower conversion rate, shorter length of stay, and fewer complications than laparoscopic cholecystectomy, despite a longer operative time, supporting its use as a safe alternative in carefully selected older patients.
References
Strasberg SM (2008) Clinical practice. Acute calculous cholecystitis. New England Journal of Medicine, 358(26): 2804-2811. DOI: 10.1056/NEJMcp0800929
Soper NJ, Stockmann PT, Dunnegan DL, Ashley SW (1992) Laparoscopic cholecystectomy. The new "gold standard"? Archives of Surgery, 127(8): 917-923. DOI: 10.1001/archsurg.1992.01420080051008
Shea JA, Healey MJ, Berlin JA, Clarke JR, Malet PF, Staroscik RN, et al. (1996) Mortality and complications associated with laparoscopic cholecystectomy: a meta-analysis. Annals of Surgery, 224(5): 609-620. DOI: 10.1097/00000658-199611000-00005
Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ (2006) Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis. Cochrane Database of Systematic Reviews, (4): CD006231. DOI: 10.1002/14651858.CD006231
Gutt CN, Encke J, Koninger J, Harnoss JC, Weigand K, Kipfmuller K, et al. (2013) Acute cholecystitis: early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study). Annals of Surgery, 258(3): 385-393. DOI: 10.1097/SLA.0b013e3182a1599b
Loozen CS, van Santvoort HC, van Duijvendijk P, Besselink MG, Gouma DJ, Nieuwenhuijzen GA, et al. (2018) Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE trial): multicentre randomised clinical trial. BMJ, 363: k3965. DOI: 10.1136/bmj.k3965
Gurusamy KS, Davidson C, Gluud C, Davidson BR (2013) Early versus delayed laparoscopic cholecystectomy for people with acute cholecystitis. Cochrane Database of Systematic Reviews, (6): CD005440. DOI: 10.1002/14651858.CD005440.pub3
Vetrhus M, Soreide O, Solhaug JH, Nesvik I, Soreide K (2002) Symptomatic, non-complicated gallbladder stone disease. Operation or observation? A randomized clinical study. Scandinavian Journal of Gastroenterology, 37(7): 834-839. DOI: 10.1080/003655202760230904
Yokoe M, Hata J, Takada T, Strasberg SM, Asbun HJ, Wakabayashi G, et al. (2018) Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis. Journal of Hepato-Biliary-Pancreatic Sciences, 25(1): 41-54. DOI: 10.1002/jhbp.515
Pisano M, Allievi N, Gurusamy K, Borzellino G, Cimbanassi S, Boerna D, et al. (2020) 2020 World Society of Emergency Surgery updated guidelines for the diagnosis and treatment of acute calculus cholecystitis. World Journal of Emergency Surgery, 15: 61. DOI: 10.1186/s13017-020-00336-x
Turrentine FE, Wang H, Simpson VB, Jones RS (2006) Surgical risk factors, morbidity, and mortality in elderly patients. Journal of the American College of Surgeons, 203(6): 865-877. DOI: 10.1016/j.jamcollsurg.2006.08.026
Story DA (2008) Postoperative complications in elderly patients and their significance for long-term prognosis. Current Opinion in Anaesthesiology, 21(3): 375-379. DOI: 10.1097/ACO.0b013e3282f889f8
Etzioni DA, Liu JH, O'Connell JB, Maggard MA, Ko CY (2003) Elderly patients in surgical workloads: a population-based analysis. American Surgeon, 69(11): 961-965.
Riall TS, Zhang D, Townsend CM Jr, Kuo YF, Goodwin JS (2010) Failure to perform cholecystectomy for acute cholecystitis in elderly patients is associated with increased morbidity, mortality, and cost. Journal of the American College of Surgeons, 210(5): 668-679. DOI: 10.1016/j.jamcollsurg.2009.12.031
Bergman S, Sourial N, Vedel I, Hanna WC, Fraser SA, Newman D, et al. (2011) Gallstone disease in the elderly: are older patients managed differently? Surgical Endoscopy, 25(1): 55-61. DOI: 10.1007/s00464-010-1128-6
Angrisani L, Lorenzo M, De Palma G, Sivero L, Catanzano C, Tesauro B, et al. (1996) Laparoscopic cholecystectomy in geriatric patients. Surgical Laparoscopy & Endoscopy, 6(5): 357-360.
Csikesz NG, Tseng JF, Shah SA (2008) Trends in surgical management for acute cholecystitis. Surgical Endoscopy, 22(5): 1191-1196. DOI: 10.1007/s00464-007-9660-9
Fried GM, Clas D, Meakins JL (1994) Minimally invasive surgery in the elderly patient. Surgical Clinics of North America, 74(2): 375-387.
Novitsky YW, Czerniach DR, Kercher KW, Kaban GK, Gallagher-Dorval KA, Litwin DE (2007) Advantages of robotic cholecystectomy compared with standard laparoscopic cholecystectomy: results of a prospective randomized trial. Archives of Surgery, 142(1): 40-44. DOI: 10.1001/archsurg.142.1.40
Giulianotti PC, Coratti A, Angelini M, Sbrana F, Cecconi S, Balestracci T, et al. (2003) Robotics in general surgery: personal experience in a large community hospital. Archives of Surgery, 138(7): 777-784. DOI: 10.1001/archsurg.138.7.777
Breitenstein S, Nocito A, Puhan M, Held U, Weber M, Clavien PA (2008) Robotic-assisted versus laparoscopic cholecystectomy: outcome and cost analyses of a case-matched control study. Annals of Surgery, 247(6): 987-993. DOI: 10.1097/SLA.0b013e318172501f
Strosberg DS, Nguyen MC, Muscarella P, Narula VK (2017) A retrospective comparison of robotic cholecystectomy versus laparoscopic cholecystectomy: operative outcomes and cost analysis. Surgical Endoscopy, 31(3): 1436-1441. DOI: 10.1007/s00464-016-5134-0
Spinoglio G, Lenti LM, Maglione V, Lucido FS, Priora F, Bianchi PP, et al. (2012) Single-site robotic cholecystectomy (SSRC) versus single-incision laparoscopic cholecystectomy (SILC): comparison of learning curves. First European experience. Surgical Endoscopy, 26(6): 1648-1655. DOI: 10.1007/s00464-011-2087-2
Vidovszky TJ, Smith W, Ghosh J, Ali MR (2006) Robotic cholecystectomy: learning curve and cost. Journal of Surgical Research, 136(2): 172-178. DOI: 10.1016/j.jss.2006.03.021
Kudsi OY, Castellanos A, Kaza S, McCarty J, Dickens E, Martin D, et al. (2017) Cost analysis comparing robotic and laparoscopic cholecystectomy. Journal of Robotic Surgery, 11(4): 343-349.
Buchs NC, Pugin F, Volonte F, Hagen ME, Morel P (2013) Reasons for conversion from laparoscopic to robotic cholecystectomy: a retrospective analysis. Journal of Robotic Surgery, 7(3): 271-275. DOI: 10.1007/s11701-012-0367-4
Antoniou SA, Antoniou GA, Koch OO, Pointner R, Granderath FA (2011) Robot-assisted laparoscopic surgery of the biliary tract. Journal of the Society of Laparoendoscopic Surgeons, 15(2): 177-185. DOI: 10.4293/108680811X13022985132074
Ambe PC, Weber SA, Christ H, Wassenberg D (2014) Cholecystectomy for acute cholecystitis. How time-critical are the so-called "golden 72 hours"? A case control study. World Journal of Emergency Surgery, 9: 60. DOI: 10.1186/1749-7922-9-60
Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. (2009) The Clavien-Dindo classification of surgical complications: five-year experience. Annals of Surgery, 250(2): 187-196. DOI: 10.1097/SLA.0b013e3181b13ca2
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Annals of Surgery, 240(2): 205-213. DOI: 10.1097/01.sla.0000133083.54934.ae
Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. Journal of Chronic Diseases, 40(5): 373-383. DOI: 10.1016/0021-9681(87)90171-8
Glasgow RE, Cho M, Hutter MM, Mulvihill SJ (2000) The spectrum and cost of complicated gallstone disease in California. Archives of Surgery, 135(9): 1021-1027. DOI: 10.1001/archsurg.135.9.1021
Published
Issue
Section
License
Copyright (c) 2026 Cormac O'Brien, et al.

This work is licensed under a Creative Commons Attribution 4.0 International License.

