Comparative Analysis of corneal transplantation versus Standard Care in diabetic retinopathy
DOI:
https://doi.org/10.5281/zenodo.22811908Keywords:
corneal transplantation, diabetic retinopathy, keratoplasty, endothelial keratoplasty, anti-VEGF therapyAbstract
Background: Diabetic retinopathy is the leading cause of preventable blindness in working-age adults, and diabetes also produces a distinct corneal endothelial phenotype relevant to transplantation [6,7].
Objective: This review compares outcomes of corneal transplantation, including penetrating and endothelial keratoplasty, in diabetic recipients against standard, non-transplant care for diabetic retinopathy.
Methods: We synthesized keratoplasty outcome cohorts, eye-bank registry data, corneal endothelial physiology studies, and landmark diabetic retinopathy treatment trials from the PubMed-indexed ophthalmology literature.
Findings: Diabetes modestly accelerates endothelial cell loss after penetrating keratoplasty [21,23], an effect attenuated by endothelial lamellar techniques [26,25]; standard retinopathy care rests on a far larger trial base, with anti-VEGF now matching or exceeding photocoagulation [29,31].
Conclusions: Transplantation and standard retinopathy care address complementary problems; diabetic keratoplasty candidates warrant baseline endothelial assessment and sequencing around retinal stability [9,3].
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