Clinical Outcomes of phacoemulsification cataract surgery in Patients with primary open-angle glaucoma
DOI:
https://doi.org/10.5281/zenodo.22812172Keywords:
phacoemulsification, cataract surgery, primary open-angle glaucoma, intraocular pressure, micro-invasive glaucoma surgeryAbstract

Background: Cataract and primary open-angle glaucoma (POAG) frequently coexist in aging populations, and phacoemulsification is increasingly performed alone or combined with micro-invasive glaucoma surgery (MIGS) in these patients [1].
Objective: This review synthesizes clinical outcomes of phacoemulsification cataract surgery in POAG patients, including intraocular pressure (IOP) change, medication burden, glaucoma progression, and outcomes of combined phaco-MIGS approaches.
Methods: We reviewed randomized trials, prospective and retrospective cohort studies, foundational glaucoma treatment trials, and society guideline documents addressing IOP and medication outcomes after phacoemulsification in open-angle glaucoma.
Findings: Phacoemulsification alone produces a sustained, angle-dependent IOP reduction in POAG eyes that exceeds the effect in nonglaucomatous eyes [9,12], and combining phacoemulsification with a trabecular or Schlemm's canal MIGS device significantly increases the proportion of eyes reaching unmedicated target IOP compared with phacoemulsification alone [21,23].
Conclusions: Surgical planning for POAG patients undergoing cataract surgery should be individualized by baseline pressure, angle configuration, and prior filtration surgery status, with postoperative IOP surveillance remaining essential regardless of technique chosen [33,30].
References
Tham, Y.C., Li, X., Wong, T.Y., Quigley, H.A., Aung, T., Cheng, C.Y. (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology, 121(11): 2081-2090. DOI: 10.1016/j.ophtha.2014.05.013
Quigley, H.A., Broman, A.T. (2006) The number of people with glaucoma worldwide in 2010 and 2020. British Journal of Ophthalmology, 90(3): 262-267. DOI: 10.1136/bjo.2005.081224
Hayashi, K., Hayashi, H., Nakao, F., Hayashi, F. (2000) Changes in anterior chamber angle width and depth after phacoemulsification in eyes with glaucoma. Ophthalmology, 107(4): 698-703. DOI: 10.1016/s0161-6420(00)00007-8
Huang, G., Gonzalez, E., Peng, P.H., Lee, R., Leeungurasatien, T., He, M., et al. (2011) Anterior chamber depth, iridocorneal angle width, and intraocular pressure changes after phacoemulsification: narrow vs open iridocorneal angles. Archives of Ophthalmology, 129(10): 1283-1290. DOI: 10.1001/archophthalmol.2011.272
Weinreb, R.N., Aung, T., Medeiros, F.A. (2014) The pathophysiology and treatment of glaucoma: a review. JAMA, 311(18): 1901-1911. DOI: 10.1001/jama.2014.3192
European Glaucoma Society (2017) Terminology and Guidelines for Glaucoma, 4th Edition. British Journal of Ophthalmology, 101(4): 73-127. DOI: 10.1136/bjophthalmol-2016-EGSguideline.001
Kung, J.S., Choi, D.Y., Cheema, A.S., Singh, K. (2015) Cataract surgery in the glaucoma patient. Middle East African Journal of Ophthalmology, 22(1): 10-17. DOI: 10.4103/0974-9233.148343
Shrivastava, A., Singh, K. (2010) The effect of cataract surgery on intraocular pressure. Current Opinion in Ophthalmology, 21(2): 118-122. DOI: 10.1097/ICU.0b013e3283360bee
Mathalone, N., Hyams, M., Neiman, S., Buckman, G., Hod, Y., Geyer, O. (2005) Long-term intraocular pressure control after clear corneal phacoemulsification in glaucoma patients. Journal of Cataract and Refractive Surgery, 31(3): 479-483. DOI: 10.1016/j.jcrs.2004.06.046
Shingleton, B.J., Pasternack, J.J., Hung, J.W., O'Donoghue, M.W. (2006) Three and five year changes in intraocular pressures after clear corneal phacoemulsification in open angle glaucoma patients, glaucoma suspects, and normal patients. Journal of Glaucoma, 15(6): 494-498. DOI: 10.1097/01.ijg.0000212294.31411.92
Shingleton, B.J., Laul, A., Nagao, K., Wolff, B., O'Donoghue, M., Eagan, E., et al. (2008) Effect of phacoemulsification on intraocular pressure in eyes with pseudoexfoliation glaucoma and primary open-angle glaucoma. Journal of Cataract and Refractive Surgery, 34(11): 1834-1841. DOI: 10.1016/j.jcrs.2008.06.031
Poley, B.J., Lindstrom, R.L., Samuelson, T.W., Schulze, R. Jr. (2009) Intraocular pressure reduction after phacoemulsification with intraocular lens implantation in glaucomatous and nonglaucomatous eyes: evaluation of a causal relationship between the natural lens and open-angle glaucoma. Journal of Cataract and Refractive Surgery, 35(11): 1946-1955. DOI: 10.1016/j.jcrs.2009.05.061
Mansberger, S.L., Gordon, M.O., Jampel, H., Bhorade, A., Brandt, J.D., Wilson, B., et al. (2012) Reduction in intraocular pressure after cataract extraction: the Ocular Hypertension Treatment Study. Ophthalmology, 119(9): 1826-1831. DOI: 10.1016/j.ophtha.2012.02.050
Slabaugh, M.A., Bojikian, K.D., Moore, D.B., Chen, P.P. (2014) The effect of phacoemulsification on intraocular pressure in medically controlled open-angle glaucoma patients. American Journal of Ophthalmology, 157(1): 26-31. DOI: 10.1016/j.ajo.2013.08.023
Kim, D.D., Doyle, J.W., Smith, M.F. (1999) Intraocular pressure reduction following phacoemulsification cataract extraction with posterior chamber lens implantation in glaucoma patients. Ophthalmic Surgery and Lasers, 30(1): 37-40.
Issa, S.A., Pacheco, J., Mahmood, U., Nolan, W., Beatty, S. (2005) A novel index for the assessment of the ability of phaco alone to control intraocular pressure. BMC Ophthalmology, 5: 12. DOI: 10.1186/1471-2415-5-12
Chen, P.P., Lin, S.C., Junk, A.K., Radhakrishnan, S., Singh, K., Chen, T.C. (2015) The effect of phacoemulsification on intraocular pressure in glaucoma patients: a report by the American Academy of Ophthalmology. Ophthalmology, 122(7): 1294-1307. DOI: 10.1016/j.ophtha.2015.03.021
Armstrong, J.J., Wasiuta, T., Kiatos, E., Malvankar-Mehta, M., Hutnik, C.M. (2017) The effects of phacoemulsification on intraocular pressure and topical medication use in patients with glaucoma: a systematic review and meta-analysis of 3-year data. Journal of Glaucoma, 26(6): 511-522. DOI: 10.1097/IJG.0000000000000643
Melancia, D., Abegao Pinto, L., Marques-Neves, C. (2015) Cataract surgery and intraocular pressure. Ophthalmic Research, 53(3): 141-148. DOI: 10.1159/000377635
Merkur, A., Damji, K.F., Mintsioulis, G., Hodge, W.G. (2001) Intraocular pressure decrease after phacoemulsification in patients with pseudoexfoliation syndrome. Journal of Cataract and Refractive Surgery, 27(4): 528-532. DOI: 10.1016/s0886-3350(00)00641-4
Samuelson, T.W., Katz, L.J., Wells, J.M., Duh, Y.J., Giamporcaro, J.E. (2011) Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract. Ophthalmology, 118(3): 459-467. DOI: 10.1016/j.ophtha.2010.07.007
Craven, E.R., Katz, L.J., Wells, J.M., Giamporcaro, J.E. (2012) Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: two-year follow-up. Journal of Cataract and Refractive Surgery, 38(8): 1339-1345. DOI: 10.1016/j.jcrs.2012.03.025
Samuelson, T.W., Sarkisian, S.R. Jr., Lubeck, D.M., Stiles, M.C., Duh, Y.J., Romo, E.A., et al. (2019) Prospective, randomized, controlled pivotal trial of a Schlemm canal microstent (Hydrus) to reduce intraocular pressure in primary open-angle glaucoma and cataract: the HORIZON study. Ophthalmology, 126(1): 29-37. DOI: 10.1016/j.ophtha.2018.05.012
Vold, S., Ahmed, I.I.K., Craven, E.R., Mattox, C., Stamper, R., Packer, M., et al. (2016) Two-year COMPASS trial results: supraciliary microstenting with phacoemulsification in patients with open-angle glaucoma and cataracts. Ophthalmology, 123(10): 2103-2112. DOI: 10.1016/j.ophtha.2016.06.032
Fea, A.M., Belda, J.I., Rekas, M., Junemann, A., Chang, L., Pablo, L., et al. (2018) Prospective unmasked randomized evaluation of the iStent inject versus two ocular hypotensive agents in patients with primary open-angle glaucoma. Clinical Ophthalmology, 12: 2601-2610. DOI: 10.2147/OPTH.S200343
Friedman, D.S., Jampel, H.D., Lubomski, L.H., Kempen, J.H., Quigley, H., Congdon, N., et al. (2002) Surgical strategies for coexisting glaucoma and cataract: an evidence-based update. Ophthalmology, 109(10): 1902-1913. DOI: 10.1016/s0161-6420(02)01267-8
Husain, R., Liang, S., Foster, P.J., Gazzard, G., Bunce, C., Chew, P.T., et al. (2012) Cataract surgery after trabeculectomy: the effect on trabeculectomy function. Archives of Ophthalmology, 130(2): 165-170. DOI: 10.1001/archophthalmol.2011.334
Gedde, S.J., Schiffman, J.C., Feuer, W.J., Herndon, L.W., Brandt, J.D., Budenz, D.L. (2012) Treatment outcomes in the Tube Versus Trabeculectomy (TVT) Study after five years of follow-up. American Journal of Ophthalmology, 153(5): 789-803. DOI: 10.1016/j.ajo.2011.10.026
Tham, C.C., Kwong, Y.Y., Baig, N., Leung, D.Y., Li, F.C., Lam, D.S. (2013) Phacoemulsification versus trabeculectomy in medically uncontrolled chronic angle-closure glaucoma without cataract. Ophthalmology, 120(1): 62-67. DOI: 10.1016/j.ophtha.2012.07.021
Heijl, A., Leske, M.C., Bengtsson, B., Hyman, L., Bengtsson, B., Hussein, M. (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Archives of Ophthalmology, 120(10): 1268-1279. DOI: 10.1001/archopht.120.10.1268
Leske, M.C., Heijl, A., Hussein, M., Bengtsson, B., Hyman, L., Komaroff, E. (2003) Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Archives of Ophthalmology, 121(1): 48-56. DOI: 10.1001/archopht.121.1.48
Musch, D.C., Gillespie, B.W., Niziol, L.M., Lichter, P.R., Varma, R. (2006) Cataract extraction in the Collaborative Initial Glaucoma Treatment Study: incidence, risk factors, and the effect of cataract progression on visual field. Ophthalmology, 113(8): 1247-1255. DOI: 10.1016/j.ophtha.2006.03.023
AGIS Investigators (2000) The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. American Journal of Ophthalmology, 130(4): 429-440. DOI: 10.1016/s0002-9394(00)00538-9
Kass, M.A., Heuer, D.K., Higginbotham, E.J., Johnson, C.A., Keltner, J.L., Miller, J.P., et al. (2002) The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Archives of Ophthalmology, 120(6): 701-713. DOI: 10.1001/archopht.120.6.701
Coleman, A.L., Lum, F.C. (2016) IRIS registry analyses of cataract surgery outcomes in glaucoma patients. American Journal of Ophthalmology, 172: 1-2.
Brubaker, R.F. (2001) Delayed functional loss in glaucoma. American Journal of Ophthalmology, 132(4): 464-468. DOI: 10.1016/s0002-9394(01)01144-8
Published
Issue
Section
License
Copyright (c) 2021 Luca Greco, et al.

This work is licensed under a Creative Commons Attribution 4.0 International License.