Long-Term Follow-Up of gold nanoparticle-based therapy for chronic wounds

Ying Huang; J. Zhao; F. Huang

doi:10.5281/zenodo.22811880

Authors

Ying Huang Department of Nanomedicine, Narmada Center for Nanomedicine Author https://orcid.org/5816-0447-5027-884X
J. Zhao Department of Clinical Nanomaterials Science, Brahmaputra Center for Nanomaterials Science Author https://orcid.org/2137-7688-5538-9567
F. Huang Department of Clinical Nanomaterials Science, Amur Center for Nanomaterials Science Author https://orcid.org/2472-0311-2925-3488

DOI:

https://doi.org/10.5281/zenodo.22811880

Keywords:

gold nanoparticles, chronic wounds, wound healing, antimicrobial nanomedicine, biodistribution

Abstract

Graphical abstract

Background: Gold nanoparticles combine photothermal, antibacterial, and immunomodulatory properties, making them a studied platform for chronic wounds, which affect 6.5 million US patients and cost over $25 billion annually [1].

Objective: This review synthesizes evidence on gold nanoparticle-based therapy for chronic wounds, emphasizing long-term wound-healing efficacy and systemic biodistribution and safety.

Methods: We synthesized in vitro antibacterial studies, animal wound models, comparative metal nanoparticle reviews, and toxicological studies reporting biodistribution beyond the acute dosing window.

Findings: Gold nanoparticles disrupt bacterial membranes and metabolism [5,6], accelerate closure of infected and diabetic wounds combined with peptides or photothermal activation [13,20], and drive macrophage M2 polarization [21]; rodent studies show organ retention for weeks to months without an alarming toxicity signal [22,23,24].

Conclusions: Gold nanoparticle-based chronic wound therapies rest on a coherent preclinical literature, but genuine long-term follow-up remains the critical gap before mainstream use [3,4].

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