Comparative Analysis of nanorobotic drug delivery versus Standard Care in chronic wounds

Li Wang; J. Wu; M. Zhou

doi:10.5281/zenodo.22811861

Authors

Li Wang Department of Nanomaterials Science, Amur Center for Nanomaterials Science Author https://orcid.org/1155-8747-2143-2292
J. Wu Department of Clinical Nanomaterials Science, Narmada Center for Nanomedicine Author https://orcid.org/9905-1458-6676-0251
M. Zhou Department of Nanomaterials Science, Kama Research Center for Nanomedicine Author https://orcid.org/5898-0904-7716-878X

DOI:

https://doi.org/10.5281/zenodo.22811861

Keywords:

nanorobotics, drug delivery, chronic wounds, wound healing, standard care

Abstract

Graphical abstract

Background: Chronic wounds stall in the inflammatory phase and resist standard care, driving nanomedicine research from passive antimicrobial dressings toward actively propelled, logic-gated nanorobotic delivery.

Objective: This review compares outcome evidence for nanorobotic and nanoparticle-based drug delivery in chronic wounds against standard wound care and its passive-nanoparticle extensions.

Methods: We conducted a narrative, comparative synthesis of studies reporting quantifiable wound outcomes for nanorobotic platforms, alongside randomized trials of standard care, silver-based dressings, and growth-factor delivery.

Findings: Randomized trials show silver dressings and growth-factor therapy each produce measurable, incremental gains over bare standard care; actively targeted nanorobot platforms report larger delivery-efficiency advantages preclinically, but none has been compared directly against standard chronic-wound care.

Conclusions: Nanorobotic delivery remains mechanistically promising but clinically unproven in chronic wounds; standard care and its trial-supported nanoparticle extensions remain the appropriate default until randomized comparison exists.

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