Comparative Analysis of nanorobotic drug delivery versus Standard Care in bacterial infections
DOI:
https://doi.org/10.5281/zenodo.22811829Keywords:
nanorobots, targeted drug delivery, biofilm penetration, antimicrobial resistance, bacterial infectionAbstract
Background: Rising resistance and poor biofilm penetration by systemic antibiotics have driven interest in nanorobotic and self-propelled nanocarrier platforms as an alternative to standard antibiotic administration [2,3].
Objective: This review compares preclinical evidence for nanorobotic and actively propelled nanocarrier delivery against standard, passively diffusing antibiotic administration in bacterial infection models.
Methods: We synthesized in vivo and in vitro comparative studies of micro/nanorobots, membrane-coated nanoparticles, and triggered-release nanocarriers against free-drug controls in bacterial infection and biofilm models.
Findings: Self-propelled micromotors achieved markedly greater local retention and clearance than passive antibiotic in a mouse stomach infection model [7], hybrid nanorobots removed both pathogens and toxins in one platform [18,17], and triggered-release or nanobubble-assisted carriers improved antibiotic penetration through biofilms relative to free drug [12,15,14].
Conclusions: Active or targeted nanocarrier delivery consistently outperformed standard antibiotic administration on biofilm penetration and local clearance, though translation still depends on scalable propulsion and regulatory validation [4,6].
References
Rai, M., Yadav, A., Gade, A. (2009) Silver nanoparticles as a new generation of antimicrobials. Biotechnology Advances, 27(1): 76-83. DOI: 10.1016/j.biotechadv.2008.09.002
Huh, A.J., Kwon, Y.J. (2011) "Nanoantibiotics": A new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. Journal of Controlled Release, 156(2): 128-145. DOI: 10.1016/j.jconrel.2011.07.002
Wang, B., Kostarelos, K., Nelson, B.J., Zhang, L. (2021) Trends in Micro-/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications. Advanced Materials, 33(4): 2002047. DOI: 10.1002/adma.202002047
Soto, F., Wang, J., Ahmed, R., Demirci, U. (2020) Medical Micro/Nanorobots in Precision Medicine. Advanced Science, 7(21): 2002203. DOI: 10.1002/advs.202002203
Gao, W., Thamphiwatana, S., Angsantikul, P., Zhang, L. (2014) Nanoparticle approaches against bacterial infections. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 6(6): 532-547. DOI: 10.1002/wnan.1282
Kalhapure, R.S., Suleman, N., Mocktar, C., Seedat, N., Govender, T. (2015) Nanoengineered drug delivery systems for enhancing antibiotic therapy. Journal of Pharmaceutical Sciences, 104(3): 872-905. DOI: 10.1002/jps.24298
Esteban-Fernández de Ávila, B., Angsantikul, P., Li, J., Lopez-Ramirez, M.A., Ramírez-Herrera, D.E., Thamphiwatana, S., et al. (2017) Micromotor-enabled active drug delivery for in vivo treatment of stomach infection. Nature Communications, 8: 272. DOI: 10.1038/s41467-017-00309-w
Park, B.W., Zhuang, J., Yasa, O., Sitti, M. (2017) Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery. ACS Nano, 11(9): 8910-8923. DOI: 10.1021/acsnano.7b03207
Villa, K., Krejčová, L., Novotný, F., Heger, Z., Sofer, Z., Pumera, M. (2018) Cooperative Multifunctional Self-Propelled Paramagnetic Microrobots with Chemical Handles for Cell Manipulation and Drug Delivery. Advanced Functional Materials, 28(43): 1804343. DOI: 10.1002/adfm.201804343
Felfoul, O., Mohammadi, M., Taherkhani, S., de Lanauze, D., Zhong Xu, Y., Loghin, D., et al. (2016) Magneto-aerotactic bacteria deliver drug-containing nanoliposomes to tumour hypoxic regions. Nature Nanotechnology, 11: 941-947. DOI: 10.1038/nnano.2016.137
Forier, K., Messiaen, A.S., Raemdonck, K., Deschout, H., Rejman, J., De Baets, F., et al. (2013) Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy. Nanomedicine, 8(6): 935-949. DOI: 10.2217/nnm.12.129
Forier, K., Raemdonck, K., De Smedt, S.C., Demeester, J., Coenye, T., Braeckmans, K. (2014) Lipid and polymer nanoparticles for drug delivery to bacterial biofilms. Journal of Controlled Release, 190: 607-623. DOI: 10.1016/j.jconrel.2014.03.055
Messiaen, A.S., Forier, K., Nelis, H., Braeckmans, K., Coenye, T. (2013) Transport of nanoparticles and tobramycin-loaded liposomes in Burkholderia cepacia complex biofilms. PLoS ONE, 8(11): e79220. DOI: 10.1371/journal.pone.0079220
Meers, P., Neville, M., Malinin, V., Scotto, A.W., Sardaryan, G., Kurumunda, R., et al. (2008) Biofilm penetration, triggered release and in vivo activity of inhaled liposomal amikacin in chronic Pseudomonas aeruginosa lung infections. Journal of Antimicrobial Chemotherapy, 61(4): 859-868. DOI: 10.1093/jac/dkn059
Teirlinck, E., Xiong, R., Brans, T., Forier, K., Fraire, J., Van Acker, H., et al. (2018) Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms. Nature Communications, 9: 4518. DOI: 10.1038/s41467-018-06884-w
Rukavina, Z., Vanić, Ž. (2016) Current Trends in Development of Liposomes for Targeting Bacterial Biofilms. Pharmaceutics, 8(2): 18. DOI: 10.3390/pharmaceutics8020018
Hu, C.M., Fang, R.H., Copp, J., Luk, B.T., Zhang, L. (2013) A biomimetic nanosponge that absorbs pore-forming toxins. Nature Nanotechnology, 8: 336-340. DOI: 10.1038/nnano.2013.54
Esteban-Fernández de Ávila, B., Angsantikul, P., Ramírez-Herrera, D.E., Soto, F., Teymourian, H., Dehaini, D., et al. (2018) Hybrid biomembrane-functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins. Science Robotics, 3(18): eaat0485. DOI: 10.1126/scirobotics.aat0485
Angsantikul, P., Thamphiwatana, S., Zhang, L., Gao, W., Zhang, L. (2015) Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform. Vaccines, 3(4): 814-828. DOI: 10.3390/vaccines3040814
Gao, W., Fang, R.H., Thamphiwatana, S., Luk, B.T., Li, J., Angsantikul, P., et al. (2015) Modulating Antibacterial Immunity via Bacterial Membrane-Coated Nanoparticles. Nano Letters, 15(2): 1403-1409. DOI: 10.1021/nl504798g
Angsantikul, P., Thamphiwatana, S., Gao, W., Zhang, L. (2018) Coating Nanoparticles with Gastric Epithelial Cell Membrane for Targeted Antibiotic Delivery against Helicobacter pylori Infection. Advanced Therapeutics, 1(2): 1800016. DOI: 10.1002/adtp.201800016
Ussia, M., Urso, M., Dolezelikova, K., Michalkova, H., Adam, V., Pumera, M. (2021) Active Light-Powered Antibiofilm ZnO Micromotors with Chemically Programmable Properties. Advanced Functional Materials, 31(46): 2101178. DOI: 10.1002/adfm.202101178
Oral, C.M., Ussia, M., Pumera, M. (2022) Hybrid Enzymatic/Photocatalytic Degradation of Antibiotics via Morphologically Programmable Light-Driven ZnO Microrobots. Small, 18(31): 2202600. DOI: 10.1002/smll.202202600
Diallo, K., Dublanchet, A. (2022) Benefits of Combined Phage-Antibiotic Therapy for the Control of Antibiotic-Resistant Bacteria: A Literature Review. Antibiotics, 11(7): 839. DOI: 10.3390/antibiotics11070839
Published
Issue
Section
License
Copyright (c) 2022 Hao Wang, et al.
This work is licensed under a Creative Commons Attribution 4.0 International License.
