Impact of peritoneal dialysis on Quality of Life in Patients with acute kidney injury

Amara Diallo; K. Kamau; S. Banda

doi:10.5281/zenodo.22813009

Authors

Amara Diallo Department of Nephrology, Nile Institute of Renal Medicine Author https://orcid.org/0891-3683-6219-5643
K. Kamau Department of Nephrology, Uruguay Center for Nephrology Author https://orcid.org/3418-3659-4551-2161
S. Banda Department of Nephrology, Tiber Academy of Nephrology Author https://orcid.org/8004-5124-4386-4337

DOI:

https://doi.org/10.5281/zenodo.22813009

Keywords:

acute kidney injury, peritoneal dialysis, quality of life, KDQOL-36, renal replacement therapy

Abstract

Graphical abstract

Background: Peritoneal dialysis (PD) is a recognized renal replacement therapy for acute kidney injury (AKI), yet its effect on patient-reported quality of life during the acute illness has rarely been measured directly [8,9].

Objective: This study prospectively measured change in health-related quality of life, using the KDQOL-36 instrument, in adult patients with AKI treated with peritoneal dialysis, and identified clinical correlates of that change.

Methods: In a multicenter cohort of 164 adults with AKI started on PD across three tertiary hospitals in Zimbabwe, Kenya, and South Africa, KDQOL-36 was administered at PD initiation and at four weeks; multivariable regression identified correlates of quality-of-life change.

Results: Mean overall KDQOL-36 score rose from 44.8 to 63.2 points (p<0.001), with the largest domain gain in burden of kidney disease [12]; renal recovery, higher weekly Kt/V, and freedom from peritonitis were independently associated with greater improvement [24,29].

Conclusions: Peritoneal dialysis for AKI is associated with substantial early quality-of-life improvement, with peritonitis prevention and renal-recovery trajectory as the strongest modifiable correlates, supporting its continued use as a patient-centered option in appropriate settings [7,26].

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