Impact of continuous glucose monitoring on Quality of Life in Patients with insulin resistance

Liam Kelly; F. O'Brien; N. Gallagher

doi:10.5281/zenodo.22812565

Authors

Liam Kelly Department of Clinical Metabolic Disease, Volga Academy of Diabetes and Endocrinology Author https://orcid.org/9303-2940-9121-8398
F. O'Brien Department of Clinical Metabolic Disease, Po Institute for Advanced Diabetes and Endocrinology Author https://orcid.org/5401-6020-3646-8811
N. Gallagher Department of Clinical Metabolic Disease, Yukon Center for Metabolic Disease Author https://orcid.org/0424-1531-6977-9460

DOI:

https://doi.org/10.5281/zenodo.22812565

Keywords:

continuous glucose monitoring, insulin resistance, quality of life, diabetes distress, type 2 diabetes

Abstract

Graphical abstract

Background: CGM has established glycemic benefits in insulin-treated diabetes, but its effect on quality of life (QoL) in patients whose core problem is insulin resistance is less consistently synthesized.

Objective: To synthesize evidence on CGM and QoL, distress, and hypoglycemia fear in insulin-resistant and insulin-treated populations, using type 1 diabetes trials as a comparator.

Methods: We synthesized randomized trials, cohort studies, and reviews reporting validated QoL, distress, or satisfaction outcomes alongside CGM or flash monitoring.

Findings: CGM reduced hypoglycemia fear and improved satisfaction most consistently in type 1 diabetes, with smaller but consistent benefit in insulin-treated type 2 diabetes; distress responded favorably rather than worsening, while evidence in non-diabetic insulin resistance remains sparse.

Conclusions: CGM offers a genuine, population-dependent QoL benefit in insulin resistance, and future trials should prioritize QoL endpoints in type 2 diabetes and non-diabetic insulin-resistant states.

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